Pour en savoir plus : https://new.societechimiquedefrance.fr/divisions/chimie-organique/prix-et-laureats-chimie-organique/

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Titre intermédiaire

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Ce stand a été réalisé dans le cadre d'une action coordonnée par le CNRS Alsace afin de mettre en avant auprès du grand public les projets financés récemment par l'ANR (Agence Nationale pour la Recherche). Ainsi, c'est le projet C-Sil, visant la synthèse et l'étude d'hétérocycles silylés qui a été mis à l'honneur (M. Donnard).

9:30         Ouverture

10:00       Pr Michael Willis - New functional groups for synthetic and discovery chemistry 

11:00       Baptiste Dupouy - Synthesis of chemical tools to decipher the modes of action of antiparasitic redox-active 3-benzylmenadiones

11:15       Dr Maria Garcia-Avello Mendez - NHC-nickel particles for catalytic hydrogenations and reductive aminations in organic soivents or water

11:30       Mylène Lang - Stereocontrolled synthesis of new glycomimetics via transition-metal-catalyzed functionalizations of exo-alycals

Break-it-to-Make-it Strategies for Chemical Synthesis Inspired by Complex Natural Products

A cette occasion, un mini-symposium a été organisé avec des chercheurs de notre département :

Dr Nicolas Blanchard
Total Synthesis of Mycolactones A/B, Exotoxins of Buruli Ulcer

Dr Anne Bodlenner
Mutivalency Undressed

Dr Sabine Choppin
Towards the Synthesis of Terpenoid Derivatives and Strained Cyclophanes

Dr Morgan Cormier
Near-Infrared Photocatalysis for Organic Synthesis

Dr Morgan Donnard
Ynamide Carbosilylations as Key Steps to Access Valuable Captodative Enamides

Pour en savoir plus : http://www.cercle-gutenberg.fr/titulaires-et-laureats/prix-guy-ourisson-et-autres-prix-jeunes-chercheurs/biographie-prix-ourisson/prix-2022/vincent-bizet/

Regio- and Stereoselective Hydroelementation of SF₅-Alkynes and Further Functionalizations.
Lucas Popek, Dr. Jorge Juan Cabrera-Trujillo, Dr. Vincent Debrauwer, Dr. Nicolas Blanchard, Dr. Karinne Miqueu, Dr. Vincent Bizet
Angew. chem. Int. Ed., 2023, 61, e202300685
https://onlinelibrary.wiley.com/doi/10.1002/anie.202300685

Abstract

Herein is described a fully regio- and stereoselective hydroelementation reaction of SF₅-alkynes with N, O and S-nucleophiles and further functionalization of the corresponding Z-(hetero)vinyl-SF₅ intermediates, a suitable platform to access α-SF₅ ketones and esters, β-SF₅ amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF₅- and CF₃-alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.

Direct Deprotonative Functionalization of α,α-Difluoromethyl Ketones using a Catalytic Organosuperbase
Amélia Messara, Dr. Armen Panossian, Dr. Koichi Mikami, Dr. Gilles Hanquet, Dr. Frédéric R. Leroux
Angew. Chem. Int. Ed., 2023, 61, e202215899
https://onlinelibrary.wiley.com/doi/10.1002/anie.202215899

Abstract

The deprotonation of α,α-difluoromethyl ketones is underinvestigated due to the instability of the generated carbanion that can evolve into a fluorocarbene. A method for the deprotonative functionalization of these compounds is described herein under an organocatalytic system using various electrophiles, and is also applied to a related α,α-difluoromethyl sulfoxide. This strategy gives access to highly valuable difluoromethylene scaffolds.