Scientific production

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E. Colucci-Guyon; A. Rifflet; S. Saint-Auret; A.da Costa and L. Boucontet; T. Laval; C. Prehaud; N. Blanchard; J.-P. Levraud; I. G. Boneca; C. Demangel; L. Guenin-Mace

Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system Journal Article

PLOS Neglected Tropical Diseases 2020, 14, e0008878.

Links | Tags: BSM


D. Burton; Y. Wang; V. Bizet; D. Cahard

Pentafluorosulfanyl Chloride Journal Article

Encyclopedia of Reagents for Organic Synthesis 2020,.

Links | Tags: BSM


V. Debrauwer; A. Turlik; L. Rummler; A. Prescimone; N. Blanchard; K. N. Houk; V. Bizet

Ligand-Controlled Regiodivergent Palladium-Catalyzed Hydrogermylation of Ynamides Journal Article

Journal of the American Chemical Society 2020, 142, 11153-11164.

Links | Tags: BSM


N. Brach; V. Le Fouler; V. Bizet; M. Lanz; F. Gallou; C. Bailly; P. Hoehn; M. Parmentier; N. Blanchard

Optimized Synthesis of 7-Azaindazole by a Diels–Alder Cascade and Associated Process Safety Journal Article

Organic Process Research & Development 2020, 24, 776-786.

Links | Tags: BSM


Y. Liu; L. Lam; J. Ye; N. Blanchard; C. Ma

DABCO-promoted diaryl thioether formation by metal-catalyzed coupling of sodium sulfinates and aryl iodides Journal Article

Advanced Synthesis and Catalysis 2020, 362, 2326-2331.

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Y. Qiu; S. Chan; L. Lin; T. Lam Shek; T. Fung Tsang; Y. Zhang; M. Ip; P. Kay-sheung Chan; N. Blanchard; G. Hanquet; Z. Zuo; X. Yang; C. Ma

Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins Journal Article

Bioorganic Chemistry 2019, 92, 103203.

Links | Tags: BSM, SYNCAT


V. Le Fouler; Y. Chen; V. Gandon; V. Bizet; C. Salome; T. Fessard; F. Liu; K. N. Houk; N. Blanchard

Activating pyrimidines by pre-distortion for the general synthesis of 7-aza-indazoles from 2-hydrazonylpyrimidines via intramolecular Diels-Alder reactions Journal Article

Journal of American Chemical Society 2019, 141, 15901-15909.

Abstract | Links | Tags: BSM


C. Theunissen; P. Thilmany; M. Lahboubi; N. Blanchard; G. Evano

Synthesis of Ynamides by Copper-Mediated Coupling of 1,1-Dibromo-1-alkenes with Nitrogen Nucleophiles. Preparation of 4-Methyl-N-(2-phenylethynyl)-N-(phenylmethyl)benzenesulfonamide Journal Article

Organic Syntheses 2019, 96, 195-213.

Links | Tags: BSM


Y. Qiu; S. Ting Chan; L. Lin; T. L. Shek; T. F. Tsang; N. Barua; Y. Zhang; M. Ip; P. K.-S. Chan; N. Blanchard; G. Hanquet; Z. Zuo; X. Yang; C. Ma

Design, synthesis and biological evaluation of antimicrobial diarylimine and –amine compounds targeting the interaction between the bacterial NusB and NusE proteins Journal Article

European Journal of Medicinal Chemistry 2019, 178, 214 - 231.

Abstract | Links | Tags: BSM, SYNCAT


G. Zong; Z. Hu; S. O’Keefe; D. Tranter; M. J Iannotti; L. Baron; B. Hall; K. Corfield; A. O Paatero; M. J Henderson; P. Roboti; J. Zhou; X. Sun; M. Govindarajan; J. M Rohde; N. Blanchard; R. Simmonds; J. Inglese; Y. Du; C. Demangel; S. High; V. O Paavilainen; W. Q Shi

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation Journal Article

Journal of the American Chemical Society 2019, 141, 8450-8461.

Links | Tags: BSM


V. Bizet; N. Blanchard

Acid Fluorides in Transition-Metal Catalysis: A Good Balance between Stability and Reactivity Journal Article

Angewandte Chemie International Edition 2019, 58, 6814-6817.

Links | Tags: BSM


L. Naranjo; F. Ferrara; N. Blanchard; C. Demangel; S. D’Angelo; M. F. Erasmus; A. A. Teixeira; and A. R.M. Bradbury

Recombinant Antibodies against Mycolactone Journal Article

Toxins 2019, 11, 346.

Links | Tags: BSM


K. Tait; S. Koh; N. Blanchard; W. Tam

Ruthenium-catalyzed ring-opening reaction of a 3-aza-2-oxabicyclo[2.2.1]hept-5-ene with amines - an unexpected mode of ring-opening Journal Article

Canadian Journal of Chemistry 2019, 97, 310-316.

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F.J. Bauer; P.C. Thomas; S.Y. Fouchard; S.J.M. Neunlist

High-accuracy prediction of mechanisms of action using structural alerts Journal Article

Computational Toxicology 2018, 7, 36-45.

Links | Tags: BSM, CRHI


V. Le Fouler; G. Duret; P. Bisseret; N. Blanchard

Copper-mediated synthesis of N-vinyl ynamides from N-vinyl carbamates Journal Article

Tetrahedron Letters 2018, 59, 3349 - 3352.

Links | Tags: BSM


X. Zuo; F. Morlet-Savary; M. Schmitt; D. Le Nouën; N. Blanchard; J.-P. Goddard; J. Lalevée

Novel applications of fluorescent brighteners in aqueous visible-light photopolymerization: high performance water-based coating and LED-assisted hydrogel synthesis Journal Article

Polymer Chemistry 2018, 9, 3952-3958.

Abstract | Links | Tags: BSM, CRHI, NMR Mulhouse


P. Bisseret; H. Abdelkafi; N. Blanchard

Aryl transition metal chemical warheads for protein bioconjugation Journal Article

Chemical Science 2018, 9, 5132-5144.

Abstract | Links | Tags: BSM


F.J Bauer; P. C Thomas; S. Y Fouchard; S. J M Neunlist

A new classification algorithm based on mechanisms of action Journal Article

Computational Toxicology 2018, 5, 8 - 15.

Links | Tags: BSM, CRHI



S. Saint-Auret; A.-C. Chany; V. Casarotto; C. Tresse; L. Parmentier; H. Abdelkafi; N. Blanchard

Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer Journal Article

Chimia 2017, 71, 836.

Links | Tags: BSM


S. Saint-Auret; H. Abdelkafi; D. Le Nouen; L. Guenin-Macé; C. Demangel; P. Bisseret; N. Blanchard

Modular total syntheses of mycolactone A/B and its [2H]-isotopologue Journal Article

Organic & Biomolecular Chemistry 2017, 15, 7518-7522.

Links | Tags: BSM


S. Saint-Auret; H. Abdelkafi; D. Le Nouen; P. Bisseret; N. Blanchard

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans Journal Article

Organic Chemistry Frontiers 2017, 4, 2380-2386.

Links | Tags: BSM


M. Donnard; G. Duret; P. Bisseret; N. Blanchard

Intramolecular inverse electron-demand [4+2] cycloadditions of ynamidyl-tethered pyrimidines: Comparative studies in trifluorotoluene and sulfolane Journal Article

Comptes Rendus Chimie 2017, 20, 643-647.

Links | Tags: BSM


G. Duret; R. Quinlan; B. Yin; R. E. Martin; P. Bisseret; M. Neuburger; V. Gandon; N. Blanchard

Intramolecular Inverse Electron-Demand [4+2] Cycloadditions of Ynamides with Pyrimidines: Scope and DFT Insights Journal Article

Journal of Organic Chemistry 2017, 82, 1726-1742.

Links | Tags: BSM


K. Tait; A. Horvath; N. Blanchard; W. Tam

Acid-catalyzed ring-opening reactions of a cyclopropanated 3-aza-2-oxabicyclo[2.2.1]hept-5-ene with alcohols Journal Article

Beilstein Journal of Organic Chemistry 2017, 13, 2888-2894.

Links | Tags: BSM


G. Duret; V. Le Fouler; P. Bisseret; V. Bizet; N. Blanchard

Diels–Alder and Formal Diels–Alder Cycloaddition Reactions of Ynamines and Ynamides Journal Article

European Journal of Organic Chemistry 2017, 2017, 6816-6830.

Links | Tags: BSM

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