Applied organic chemistry & heterochemistry (COHA)

Team coordinator : Frédéric Leroux - frederic.leroux[at]
Other permanent staff : Morgan Donnard - Gilles Hanquet - Armen Panossian


The group's philosophy is to develop new synthetic tools in organic chemistry for applications in both public research and industry. The COHA group focuses on 4 main research axes: Heterochemistry, Synthesis methods and catalysis, Chirality control and Sustainable methods. Our projects can be linked to one or more of the 4 research axes and can be applied to the total synthesis of complex natural products or to the synthesis of functionalized building blocks for materials science.

Research axes

In this area, we synthesize fluorinated building blocks for pharmaceutical and agrochemical applications, nitrogen- and silicon-based heterocycles, phosphorus-, sulfur-, silicon- and boron-based building blocks or reactive species for synthesis or catalysis.
Synthesis methods and catalysis
We are focusing our efforts on new synthetic tools for organic chemists based on polar organometallics, transition metal catalysts, non-metallic main group catalysts, cascade reactions and more.
Chirality control
Controlling stereochemistry is at the heart of most of our projects, particularly central and axial chirality.
Sustainable methods
Drawing on our experience in synthetic organic chemistry and our commitment to laboratory and industrial-scale applications, we focus our efforts on developing efficient and sustainable syntheses of valuable building blocks or small molecules. We use abundant metal or non-metal catalysts, domino processes, continuous flow conditions where advantageous, as well as (re)modernized activation modes such as photochemistry or electrochemistry.


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